Senior Research Associate / Associate Scientist, Preclinical - In Vivo

About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world.  "Whether it's the biological diversity of our gene editing systems or the people that help discover them, Metagenomi celebrates the diversity of life. This is achieved through a compassionate culture that acknowledges the dimensions of our diversity.  We know that when people feel a sense of inclusion and belonging in the workplace, they have a safe space to bring creativity and innovation to everything they do. We are intentional about building and maintaining a culture where people are valued and respected, there is equity in opportunities, and our respective opinions and differences matter.”   -Metagenomi Culture Committee   We are hiring an experienced Senior Research Associate/Associate Scientist to evaluate novel genome editing systems for in vivo therapeutics as a member of our growing pre-clinical research team. Reporting to the pre-clinical study Manager, you will support the design and execution of in vivo studies to advance and validate a gene editing therapeutic program and will play a key role in in vivo animal modeling for gene editing. This position contributes to characterization of Metagenomi’s therapeutic targets as well as the effects of gene editing in both animal models and assays. The successful candidate will have extensive experience with wild type and disease in vivo animal models, as well as downstream processing of in vivo samples. This role will be a hybrid position and be based in Emeryville and Albany, California. How you’ll contribute:  Perform in vivo technical procedures (IP, IV, RO subcutaneous, intramuscular); collect blood and tissue samples in the vivarium. Generate study protocols, execute in vivo experiments, downstream processing/analysis of samples and document experimental results. Lead, organize and maintain various projects running in parallel. Prepare accurate and timely data summaries and contribute to the writing of reports. Generate and analyze experimental data to present at project team meetings and departmental meetings, when applicable. Collaborate across different research teams and other functions to plan and execute in vivo experiments to help validate and analyze results and advance therapies. Must haves:    Bachelor’s degree in Animal Biology, Animal Science, Biology or a related discipline. At least four years of hands-on laboratory experience conducting in vivo studies in rodents in either academia or industry.  Hands-on in vivo procedures in rodents, including but not limited to multiple routes of administration, blood collection, dissections and necropsies is required. Background in Pharmacology, toxicology or a life sciences discipline is required. Track record of challenging oneself to enhance scientific skills and knowledge. Effective oral and written communication skills. Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities. Highly collaborative, team-oriented, and considerate of the needs of others Thrives in a fast-moving, results-oriented startup environment with urgent deadlines. Independent and self-sufficient but knows when to ask questions or seek support. Self-motivated, passionate about your work, and eager to continuously help others and learn more. Preferred additional qualifications:  Experience with cell therapy and gene editing is a plus. Hand-on experience with molecular biology and/or biochemical assay techniques (e.g., DNA/RNA extraction, ELISA, PCR etc.) Proficiency with flow cytometry. Experience with surgical models is a plus Experience with transgenic and humanized animal models is a plus. California Pay Transparency Disclosure: This position is classified as an exempt salaried position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $90,000 to $120,000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus potential, pre-IPO equity, and a comprehensive benefits plan, including 401(k) with company matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation: Family & Medical Leave Act  Equal Employment Opportunity Commission Employee Polygraph Protection Act  California Family Rights Act  California Fair Employment and Housing Act Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.