Senior Director, Protein Sciences

About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world.  "Whether it's the biological diversity of our gene editing systems or the people that help discover them, Metagenomi celebrates the diversity of life. This is achieved through a compassionate culture that acknowledges the dimensions of our diversity.  We know that when people feel a sense of inclusion and belonging in the workplace, they have a safe space to bring creativity and innovation to everything they do. We are intentional about building and maintaining a culture where people are valued and respected, there is equity in opportunities, and our respective opinions and differences matter.”   -Metagenomi Culture Committee   We are hiring a Senior Director, Protein Sciences with broad expertise in molecular biology, protein and antibody engineering. You will leverage your expertise to lead the engineering of synthetic protein constructs, including chimeric antigen receptors (CARs), for incorporation in cell therapy products. Reporting to the Chief Immunology and Cell Therapy Officer, you will be responsible for leading our Protein Sciences and Antibody group, which will oversee the generation and engineering of immune cells switch receptors, and other synthetic transgenes for incorporation on cell therapy product candidates. You will leverage your industry and academic experience in protein sciences to help lead the development of our therapeutic candidates. This role is based in Emeryville, California.  How you’ll contribute Build and lead our Protein Sciences team to help novel cell therapies for the treatment of cancer and auto-immune disorders Lead the implementation of antibody and protein engineering technologies to support engineering of our cell therapy product candidates Directly contribute to the selection and design of therapeutic candidates Motivate and lead a team of talented Scientists and Research Associates  Work collaboratively with key stakeholders in Cell Therapy and other company functions to support therapeutic candidate development Prepare accurate and timely data summaries and contribute to the writing of technical study reports, papers, patent applications, and regulatory filings Participate in regulatory interaction meetings and provide strategic communication to support IND filings. Must haves: Ph.D. in STEM-related discipline and at least ten years of highly relevant biopharma industry experience Deep technical expertise in molecular biology, antibody, and protein engineering Experience with in vivo generation and screening of antibodies and in vitro antibody platforms including phage, yeast, and/or mammalian, display libraries Deep expertise with multiple antibody formats such as mAb, scFv, Fab, and single domain antibodies (VHHs) Experience in biochemical and biophysical characterization of biologics Experience engineering bi-specific antibodies, CARs, and membrane proteins Familiarity with laboratory automation and high throughput methods for protein production, purification, and characterization Familiarity with Bioinformatics tools for sequence and structural analysis to help drive binder selection Significant experience working with CROs, outsourcing, and managing external vendor relationships for antibody and protein generation. Extremely well organized and able to efficiently manage your time and workflows, including skillfully prioritizing both long-term projects and the day-to-day responsibilities of your team Direct supervisory experience leading teams of Scientists and Research Associates with a track record of recruiting, mentoring, and developing talent Outstanding communication, collaboration, and team leadership skills. California Pay Transparency Disclosure: This position is classified as an exempt salaried position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $245,000 -$265,000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.  #LI-NG1   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus potential, pre-IPO equity, and a comprehensive benefits plan, including 401(k) with company matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation: Family & Medical Leave Act  Equal Employment Opportunity Commission Employee Polygraph Protection Act  California Family Rights Act  California Fair Employment and Housing Act Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.