Director, Therapeutic Genome Editing Specificity

We are seeking a Director, Therapeutic Genome Editing with scientific leadership experience in molecular biology and genome engineering to lead our off-target characterization efforts.  Reporting to the Vice President Preclinical Research, you will leverage your industry and academic experience in the deep characterization of precision genome editing systems, including analysis and interpretation of on/off target genome editing assays. This position will play a pivotal role in enabling Metagenomi’s next-generation gene editing therapeutics by assessing the impact on genome integrity of lead therapeutic candidates. This role is based in Emeryville, California.  How you’ll contribute Provide strategic leadership to develop and operationalize genome-wide off-target characterization methods to support the nomination of genome editing technologies for therapeutic development Motivate and lead a team of talented Scientists and Research Associates Directly contribute to the selection and design of therapeutic candidates Work collaboratively with key stakeholders to deliver pivotal genome editing specificity datasets to support therapeutic candidate development Partner with our internal bioinformatics and data science team for high throughput method development and establishment of data analysis pipelines for off-target characterization assays Prepare accurate and timely data summaries and contribute to the writing of technical study reports, papers, and patent applications Participate in regulatory interaction meetings and provide strategic communication of off-target characterization results. What you bring Ph.D. in STEM-related discipline and at least eight (8) years of biopharma industry experience At least five (5)  years of highly relevant experience leading the development of genome editing specificity assays, including on/off target analysis Substantial expertise in DNA repair pathways, mechanisms of cellular transformation, and leveraging functional genomics datasets to interpret off-target assay output  Experience working with large datasets, including UK Biobank, Finngen, and resources, i.e., GnomAD, Exome variant server, 1000 Genomes, etc. Track record of successfully operationalizing genome editing characterization workflows and developing study reports supporting regulatory filings  Exceptional quantitative skills, including experience analyzing large experimental data in partnership with computational biologists to draw statistically significant conclusions Extremely organized and able to efficiently manage your time and workflows, including skillfully prioritizing both long-term projects and the day-to-day responsibilities of your team Direct supervisory experience leading teams of Scientists and Research Associates with a track record of recruiting, mentoring, and developing talent Outstanding communication, collaboration, and team leadership skills.  California Pay Transparency Disclosure: This position is classified as an exempt salaried position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $220,000 to $250,000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.    About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:   Family & Medical Leave Act    Equal Employment Opportunity Commission   Employee Polygraph Protection Act    California Family Rights Act    California Fair Employment and Housing Act   Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.