Senior Bioinformatics Scientist

We are seeking a Senior Bioinformatics Scientist with experience in algorithm development, statistical analysis, and interpretation of on/off-target gene editing data. This position will play a crucial role in moving Metagenomi’s extensive genome-editing toolbox into the clinic by supporting our discovery and pre-clinical programs.  This role will be based in Emeryville, California. How you’ll contribute:  Optimize and develop computational algorithms for gene-editing on/off-target assays to characterize CRISPR-based gene editing profiles Assist discovery and pre-clinical teams with large-scale data analyses Provide statistical support to assess genome editing outcomes in pre-clinical studies Summarize and present findings to internal and external stakeholders What you bring: Ph.D. in Bioinformatics, Computer Science, Biostatistics, Artificial Intelligence, or related discipline with equivalent experience At least five years experience in biotech or related field, preferably working on gene editing Experience developing novel algorithms to solve bioinformatics problems Experience in CRISPR editing and off-target analysis Experience in applying bioinformatic and statistical analysis to support the nomination and development of lead therapeutic candidates Familiar with the process and requirements leading up to IND filing Expert in programming and statistical analysis in Python and R Experience with machine learning and statistics using scikit-learn and Scipy Experience interpreting and visualizing complex data using visualization tools, such as Seaborn, Plotly, matplotlib, and ggplot2 Self-motivated, passionate about your work, and eager to continuously learn Able to communicate effectively across multiple scientific disciplines     Preferred additional qualifications: Understanding of test-driven development and unit testing framework Experience with developing Nextflow pipelines, working with cloud computing systems (AWS), and building containerized data workflows to handle large-scale data streams Familiarity with software development practices such as unit testing, code reviews, and version control California Pay Transparency Disclosure: This position is classified as an exempt salaried position under the Federal Labor Standards Act.  This position's anticipated base salary range will be $150,000 to $180,000.   Depending on the position offered, you will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. #LI-NG1   About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:   Family & Medical Leave Act    Equal Employment Opportunity Commission   Employee Polygraph Protection Act    California Family Rights Act    California Fair Employment and Housing Act   Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.