Scientist I/II, Gene Editing System Protein Engineering and Optimization

We are seeking a creative and collaborative Scientist to join the Discovery division to optimize protein sequences and constructs to turn novel gene editing systems into therapeutic tools. This position will report to the Director, Protein Engineering and Optimization. It will contribute to lead system generation and optimization, including generating and screening libraries in mammalian and bacterial cells, constructing protein fusions containing novel components, and assaying and selecting improved variants. You will have the opportunity to make a lasting impact as you partner with the rest of the interdisciplinary Discovery team to build an industry-leading gene editing tool kit with a focus on CRISPR-associated transposases (CASTs) and other systems that can be leveraged for gene editing through precise, programmable integration of large DNA cargoes. This role will be based in Emeryville, California. How you’ll contribute:  Generate and screen variant libraries of metagenomics-derived proteins to identify high-performing systems Optimize complex systems through structure-driven rational protein engineering Collaborate with the mammalian cell translation team to design and test protein fusion constructs for increased cell editing efficiency and specificity Contribute to the screening for novel enzymes and constructs  Identify and implement new tools and methods utilizing expertise in protein engineering Communicate results and findings to wider teams and coordinate discovery projects with Novel Systems, Mammalian Cell Translation, Biochemistry/Biophysical, and other teams What you bring: Ph.D. in Protein Engineering, Biochemistry, or a related discipline and relevant applied protein engineering research experience Expertise and knowledge of up-to-date methods and tools for optimizing proteins based on structure/function relationships Experience  high-throughput plasmid construction and expressing proteins in mammalian cells  Experience designing and performing  high-throughput selection screens in mammalian cells Effective oral and written communication, prioritization, and organizational skills The ability to quickly learn and adapt to new projects and tools,  A highly collaborative and solutions-oriented outlook, and you thrive in a fast-moving startup environment   California Pay Transparency Disclosure: This position is classified as an exempt position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $115,000 to $145,000 .  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.    About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:   Family & Medical Leave Act    Equal Employment Opportunity Commission   Employee Polygraph Protection Act    California Family Rights Act    California Fair Employment and Housing Act   Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.