What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.Summary:The Senior Systems Engineer –Instrument Architecture will be responsible for providing leadership to cross functional teams to develop industry-leading DNA sequencing cartridges and consumables for clinical applications in an exciting, fast-paced environment. The foundation of all activities for this role is a broad, solid grasp of multiple areas of engineering, physics and molecular biology, and the ability to climb new learning curves quickly. Primary responsibilities include development of system models/budgets, contributing to system & sub-system architecture decisions, managing specifications and requirements, and developing test strategies for critical parameter understanding and verification. A successful candidate will possess strong organizational and communication skills to facilitate successful product development across hardware, firmware, software, consumables, and chemistry teams.Job Activities:Significantly contribute to developing new architectures for high volume medical device instrumentation that integrate microfluidics, chemistry, and imagingDevelop system models that guide design decisions. These can include system tolerance budgets, runtime models, SNR models, performance models, COGS models, etc.Support architecture definition by working across sub-system design teams to align overlapping design requirements /constraints and drive teams in developing concepts, evaluating risks, and efficiently concluding on a design pathLead teams through complex root-cause analysis in which there are many possible root causes that involve various areas of physicsBuild the information foundation for successful architecture activity. Create and maintain system requirements, specifications, and functional workflows. Examples include biochemistry workflows, hardware timing diagrams, and assembly process workflowsDevelop, manage, execute test strategies for Critical Parameter Management which identify the sensitivities and acceptable operating ranges for input parameters relative to output metricsLeverage Design of Experiments for efficient coverage of complex parameter spaceOwn the seams between teams, especially including the definition and documentation of interfaces between hardware, firmware, and software. Culture the ecosystem mindset in practiceRequired Skills & Experience:Engineering, Physics, Biophysics, or related master’s degree with 5+ years of experience or Ph.D. with 0 -3 years of experience in instrumentation, or product developmentHighly motivated to work cross-functionally in the ecosystem of fluidics, liquid handling, precision motion, and biochemistryStrong analytical background, with record of using system models to drive decisionsDemonstrated track record of rapidly climbing steep learning curves. Enthusiasm for tackling tough problems on an aggressive scheduleExperience with definition, setup, characterization, and testing of complex systems, including design of experiments, reliability life tests, and root cause analysisExperience and fluency in scientific computing and simulation, such as Python, MATLAB, or REffective communication and presentation skills (ability to distill complex technical information into product decisions and business recommendations)Preferred Skills & Experience:Technically proficient in disciplines of integrated devices or cartridges including plastics design & injection molding, microfluidics, heat transfer, surface chemistry, biochemistry interactions, and thermal cyclingExperience in instrument design and developmentTechnically proficient in disciplines including optics, microfluidics, heat transfer, precision motion, or electronicsExperience with specification and requirement management (JAMA), design traceability, design verification and validationExperience in process engineering methodologies such as FMEA (Failure Mode and Effects Analysis), SPC, Gauge R&R, Critical Parameter Management, and Design for Manufacturability to measure and improve process capability and robustnessFluency in the methods and vocabulary of nucleic acid analytical techniques, genetic sequencing, and molecular biology is preferredExperience with Signal-to-noise Ratio (SNR) modelingExperience developing products in a regulated environment (FDA 510k approval process)Understanding of the physics of failure approach to reliability, failure mechanisms, failure analysis techniques, and basic probability conceptsIllumina believes that everyone has the ability to make an impact, and we are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information.
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