Director – Antibody Characterization

Company: Twist Bioscience
Company: Twist Bioscience
Location: USA - Quincy, MA
Posted on: 2023-04-28 17:09
POSITION SUMMARY This director-level, management position provides support for bioanalytical characterization for a variety of therapeutic candidates. This role oversees our Antibody Characterization department and is responsible for managing, optimizing and troubleshooting a range of workflows including immunoassays, affinity analysis, functional assays and protein isolation/characterization. ESSENTIAL FUNCTIONS Lead and develop a team of scientists and research associates in our Antibody Characterization department. Provide end-to-end guidance (assay development, execution, analysis and data reporting) in areas including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), functional screening, and general protein characterization. Critically analyze and present data to facilitate antibody lead selection for a variety of concurrent discovery programs. Work closely with the Project Management team to communicate timelines and deliverables. Work closely with all scientific departments and senior management to ensure excellent management of all activities and communication. Promote growth of the team and create internal research project ideas for the team to execute to contribute to company growth. Work closely with members of senior management to promote new product ideas and support more global company growth. Stay up to date with recent developments in antibody discovery methods and technologies - help guide the progression of our laboratory capabilities and future improvements in the bioanalytical group. POSITION QUALIFICATIONS PhD in related technical field with 8+ years of experience in biopharmaceutical analytical development or BS/MS with 12+ years of experience. Expert knowledge of biologics characterization assays: extensive experience required in ELISA, FACS and SPR/BLI with Carterra and ForteBio Octet. Very strong knowledge of SDS-PAGE, CE, and HPLC. Very strong track record of developing, executing, and analyzing common assay formats for biologics discovery such as high throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and developability assays. Able to independently manage and prioritize tasks in a fast-paced environment that hinges on overlapping projects and sensitive workflow timelines. Advanced understanding of  in vivo antibody discovery. Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics. Proven management skills for both projects and larger groups of workers. Exceptional written and verbal communication skills Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics  
View Original Job Posting