Associate Director - NGS Bioinformatics

We are seeking a motivated individual with a background in biology, genomics, and programming to support and lead Metagenomi’s NGS based bioinformatics discovery platform. Reporting to the Vice President, Discovery, this position will play a crucial role in designing methods to support the development and usage of Metagenomi’s extensive genome-editing toolbox, including algorithm development, big-data analytics, and pipeline design. This role will be based in Emeryville, CA . About the Role By the end of yo ur first year , you will have a chance to demonstrate your ability to: Lead a team of bioinformaticians while collaborating closely with lab scientists and engineers to build and maintain complex NGS pipelines Develop algorithms and computational infrastructure for gene-editing applications, such as off-target analysis, guide selection, and determining editing outcomes Develop UI-based resources, command line tools, and containerized workflows for use by scientists and engineers company wide Integrate diverse data sources for improved analysis outcomes and automated pipelines (e.g. from LIMs and other internal databases) Design and implement data management best practices throughout the company Coordinate and encourage standardized coding best practices, lead and collaborate with team members on code reviews Set priorities and directions for lab/NGS data analysis, set up systems that scale, and provide communication on bioinformatics efforts company wide Desired Qualifications  PhD in Biology, Computer Science, Statistics, or closely related discipline or equivalent relevant experience At least six years of closely related bioinformatics industry experience with at least two years experience in a leadership capacity Extensive knowledge of NGS platforms, including their mechanisms and technical limitations Experience working with common bioinformatics methods for NGS data analysis (aligners, assemblers, bbmap, BEDtools, FastQC) Experience designing, troubleshooting, and optimizing complex NGS based algorithms (UMI consensus calling, RNA-seq, variant calling, analysis of gene editing outcomes,  and off target effects)  Experience with full lifecycle pipeline development Expert level proficiency in Python and experience or a strong interest in working with cloud computing systems (e.g. AWS) Experience with Docker and building containerized data workflows to handle large scale data streams Familiarity with software development practices such as unit testing, code reviews, and version control Preferred additional qualifications: AWS Well-Architected Framework, severless development Experience with machine learning applications for complex biological problems (e.g. protein engineering, functional annotation)  Experience with Nextflow , SQL & NoSQL database design Experience building front-end dashboards with Plotly Dash Experience creating data mesh architecture solutions for research  Previous experience generating data in a molecular biology/microbiology laboratory The anticipated base salary range for this position will be $170,000 - $195,000 depending on the exact level of the role. As this role is open to candidates with a wide range of skills and experience, the exact salary will be dependent on the specific level of the position. We value transparency and will make every effort to provide you with a succinct explanation for how the final salary within this range is determined. Please note, all candidates must be authorized to work in the United States.   About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:   Family & Medical Leave Act    Equal Employment Opportunity Commission   Employee Polygraph Protection Act    California Family Rights Act    California Fair Employment and Housing Act   Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.