Senior Research Associate / Scientist - iPSC-immunology

We are seeking a detail-oriented and energetic individual with expertise in human induced pluripotent stem cell (iPSC) culture and differentiation to join our Cell Therapy team. This position will play a crucial role in generating clinically-relevant iPSC-derived immune cell types. This role will be based in Emeryville, CA .   About the Role The day-to-day responsibilities of this role will include: Design and execution of iPSC-differentiation protocols into immune cells Proficiency in aseptic cell culture techniques including thawing and passaging cells, cryopreservation Characterization of iPSC-derived immune cell types using a wide range of assays including q-PCR, flow cytometry and microscopy Analyze data using ImageJ, Flowjo and Prism Contribute to in vitro assay design and optimization Present findings and data analysis in research meetings You will have a chance to demonstrate your ability to: Perform complex iPSC-differentiations to generate iPSC-derived immune cells Become an expert in all facets of iPSC cell culture, including maintenance, differentiation, and reprogramming Participate in tech transfer of research-grade protocols to GMP Collaborate with other scientists to generate a clinical-grade iPSC-product   The anticipated base salary range for this position will be $100,000 - $130,000 depending on the exact level of the role. As this role is open to candidates with a wide range of skills and experience, the exact salary will be dependent on the specific level of the position. We value transparency and will make every effort to provide you with a succinct explanation for how the final salary within this range is determined.   Desired Qualifications  Undergraduate degree in a Life Sciences and at least two years of relevant laboratory experience in academia or industry  Hands-on experience with undifferentiated iPSC culture, and maintenance is required Experience with in vitro differentiation of iPSC is required preferably towards NK and T cell lineages Molecular biology skills including mammalian cell DNA/RNA extraction, PCR/RT-PCR/qPCR Familiarity with cellular biology techniques including flow cytometry, immunocytochemistry, image analysis, and cell-based assays Demonstrated motivation to stay up-to-date on current stem cell techniques and protocols Experience with viral transduction and genomic editing using CRISPR a plus Ability to execute, troubleshoot and analyze experiments and to interpret results Precise documentation of procedures and results in compliance with Electronic Lab Notebook guidelines Effective oral and written communication skills, particularly when collaborating with other teams with limited knowledge of your area of expertise Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities Able to quickly learn and adapt to new software tools (ex: Google Suite, Slack, etc.) Highly collaborative, team-oriented, and considerate of the needs of others Thrives in a fast-moving, results-oriented startup environment with urgent deadlines Independent and self-sufficient, but knows when to ask questions or seek support Self-motivated, passionate about your work, and eager to continuously learn more.   Please note, all candidates must be authorized to work in the United States.   About Metagenomi Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.   What makes Metagenomi a unique place to work? We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease. We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!  We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.   At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.   Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:   Family & Medical Leave Act    Equal Employment Opportunity Commission   Employee Polygraph Protection Act    California Family Rights Act    California Fair Employment and Housing Act   Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.